Buy Adipotide Peptides Online

Mechanism of Action

• Homing Domain: A sequence (CKGGRAKDC) that selectively binds to receptors—primarily prohibitin-1 and annexin A2—located on the surface of blood vessels (endothelial cells) that specifically supply white fat.
• Killer Domain: A pro-apoptotic sequence ((KLAKLAK)₂) that, once internalized into the target cells, disrupts their mitochondrial membranes. 

Research Findings and Benefits

• Significant Weight Loss: Obese rhesus monkeys treated with Adipotide lost approximately 11% to 15% of their body weight over short treatment cycles (roughly 4 weeks).
• Reduced Body Fat: Studies showed up to a 38% reduction in total body fat and a 27% reduction in visceral (abdominal) fat.
• Metabolic Improvement: Independent of weight loss, research noted rapid improvements in insulin sensitivity and glucose tolerance, often within just 2-3 days of treatment.
• Reduced Food Intake: While its primary mechanism is vascular destruction, treated animals also showed a decrease in caloric consumption, potentially due to shifts in hunger hormones like leptin. 

Safety and Side Effects

• Renal Impact: Specifically, it affects the renal proximal tubules. While these changes were largely described as mild and reversible in monkeys, they remain a major concern for human development.
• Other Side Effects: Observed symptoms include mild dehydration and alterations in serum phosphorus and potassium levels.